. Author manuscript; available in PMC: 2012 Mar 1.

Published in final edited form as: Am Heart J. 2011 Jan 31;161(3):516–522. doi: 10.1016/j.ahj.2010.11.007

Table III.

Relative risks and 95% confidence intervals for CHD from the Nurses’ Health Study (1990 – 2004) according to baseline Lp-PLA₂ activity levels

	Quartiles of Lp-PLA₂				p-trend
	Q1	Q2	Q3	Q4	p-trend
Women
Cases	60	83	116	162
Controls	200	198	202	200
Mean Lp-PLA₂ (range); cases^*	107.5 (50.3 – 126.6)	142.2 (128.9 – 151.9)	163.9 (152.2 – 175.5)	209.8 (175.8 – 292.0)
Mean (range); controls^*	110.1 (45.9 – 128.0)	139.5 (128.4 – 152.1)	163.0 (152.2 – 175.7)	205.4 (175.8 – 371.4)
Matching factors adjusted model^† RR	1.0	1.46	1.93	2.86	<0.001
95% CI		0.98, 2.17	1.33, 2.80	1.98, 4.12
Multivariable + lipid adjusted model^‡ RR	1.0	1.32	1.59	1.75	0.03
95% CI		0.85, 2.05	1.03, 2.45	1.09, 2.84

Abbreviations: CHD, Coronary Heart Disease; Q, Quartile; RR, relative risk; CI, Confidence Interval

Quartiles based on the distribution of the controls

^†

RR estimated by conditional logistic regression after conditioning on matching factors (smoking, age, fasting status, month of blood draw)

^‡

Multivariable model adjusted for BMI, history of high cholesterol, history of diabetes, history of hypertension, alcohol use, aspirin use, cholesterol-lowering medication use, physical activity, CRP, HDL, postmenopausal hormone use, HDL, LDL, history of high cholesterol, and cholesterol-lowering medication use