Table IV.

Relative risks and 95% confidence intervals for CHD from the Nurses’ Health Study (1990 – 2004) according to baseline Lp-PLA₂ activity levels stratified by early vs. late events

	Quartiles of Lp-PLA2				P-trend
	Q1	Q2	Q3	Q4
EARLY (≤ 6 years of follow-up)
Women
Cases	30	50	69	94
Matching factors adjusted model* RR	1.0	1.93	2.33	3.50	<0.001
95% CI		1.13, 3.31	1.42, 3.83	2.12, 5.77
Multivariable + lipid adjusted model† RR	1.0	1.67	1.90	1.94	0.04
95% CI		0.91, 3.07	1.07, 3.40	1.04, 3.74
LATE (> 6 years of follow-up)
Women
Cases	30	33	47	68
Matching factors adjusted model* RR	1.0	1.0	1.51	2.20	<0.001
95% CI		0.55, 1.83	0.86, 2.64	1.27, 3.80
Multivariable + lipid adjusted model† RR	1.0	1.02	1.35	1.58	0.13
95% CI		0.53, 1.97	0.68, 2.68	0.74, 3.37

Abbreviations: CHD, Coronary Heart Disease; Q, Quartile; RR, relative risk; CI, Confidence Interval

^*RR estimated by conditional logistic regression after conditioning on matching factors (smoking, age, fasting status, month of blood draw)

^†Multivariable model adjusted for BMI, history of high cholesterol, history of diabetes, history of hypertension, alcohol use, aspirin use, cholesterol-lowering medication use, physical activity, CRP, postmenopausal hormone use, HDL, LDL, history of high cholesterol, and cholesterol-lowering medication use