Table V.

CHD risk reclassification^* comparing multivariable-adjusted^† logistic regression models with and without Lp-PLA₂activity among 1221 women from the Nurses’ Health Study (1990 – 2004), weighted by age and smoking categories^‡

Abbreviations: Q, Quartile; NRI, Net Reclassification Improvement Index

^*Light gray shading indicates correct reclassification with the addition of Lp-PLA₂ activity in the multivariable model (higher predicted risk for cases, lower predicted risk for controls); dark grey indicates incorrect reclassification (lower predicted risk for cases, higher predicted risk for controls); unshaded indicates no reclassification.

^†Multivariable model conditioned on matching factors (smoking, age, fasting status, month of blood draw) and adjusted for BMI, history of high cholesterol, history of diabetes, history of hypertension, alcohol use, aspirin use, cholesterol-lowering medication use, physical activity, CRP, HDL, and postmenopausal hormone use

^‡Models are weighted according to the population (total cohort) distribution of age and sex categories; thus control cells reflect the weighted individuals in the case-control sample

^§Quartiles based on the distribution of risk score from the multivariable model (without Lp-PLA₂ activity)