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. 2010 Nov 24;30(47):15843–15855. doi: 10.1523/JNEUROSCI.1425-10.2010

Figure 1.

Figure 1.

LTP is altered in mature but not young mice in a model of 22q11DS. a, b, Mean fEPSPs as a function of time in younger (a) or older (b) Df(16)1/+ mice and their WT littermates before and after induction of LTP with 200 Hz tetanization (arrow). The insets show traces of fEPSPs before, 5 min after, or 360 min after induction of LTP. **p < 0.001. c, Mean fEPSPs as a function of stimulation intensity in slices from older Df(16)1/+ and WT mice. d, Average cumulative histograms of spontaneous mEPSC amplitudes (left) and intervals (right) in CA1 neurons of older Df(16)1/+ and WT littermates. e, Evoked EPSCs (left) and their kinetics are not altered in older Df(16)1/+ mice. Representative EPSC traces (left), mean EPSC rise time and decay time (right) measured in CA1 neurons from Df(16)1/+ and WT mice.