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. 2010 Nov 24;30(47):15843–15855. doi: 10.1523/JNEUROSCI.1425-10.2010

Figure 3.

Figure 3.

Presynaptic function is affected by the Df(16)1 microdeletion in mature mice. a, PPF is enhanced in mature Df(16)1/+ mice. Mean fEPSPs as a function of the interstimulus interval (ISI) between the first and second fEPSPs evoked at CA3–CA1 synapses of WT and Df(16)1/+ mice. The inset shows representative traces of pairs of fEPSPs evoked with 20, 50, 100, or 200 ms ISIs. b–e, Short-term plasticity is enhanced in mature Df(16)1/+ mice. Typical EPSC traces (b, d) and mean peak amplitudes of EPSCs (c, e) evoked by 50 Hz (b, c) or 100 Hz (d, e) synaptic stimulations in slices from mature WT and Df(16)1/+ mice (*p < 0.05). f–h, Postsynaptic calcium transients evoked by synaptic stimulation but not by TGU are stronger in Df(16)1/+ mice. f, A TPLSM image of a CA1 pyramidal neuron dendrite. The line represents the direction of the line scan. g, h, Mean normalized Fluo 5F fluorescence (ΔG/R) in dendritic spines of CA1 neurons as a function of time with 40 synaptic (g) or TGU (h) stimulations delivered at 200 Hz. i, Mean EPSCs evoked by 40 pulses of TGU at 200 Hz at dendritic spines.