Figure 5.

Presynaptic calcium dynamics are altered in mature Df(16)1/+ mice. a, Image of an axon of a CA3 pyramidal neuron. The line represents a line scan through the presynaptic bouton. b, Average normalized Fluo 5F fluorescence measured in presynaptic boutons before and after generating 1 AP in a presynaptic neuron (*decay time, p < 0.05). c, Examples of 40 APs (200 Hz) generated in a presynaptic neuron and calcium transients evoked by 40 APs in a presynaptic bouton of a CA3 neuron in wild-type and mutant mice. d, Averaged normalized Fluo5F fluorescence measured in presynaptic boutons before and after generating 40 APs in presynaptic neurons of mature Df(16)1/+ mice and WT mice (**decay times, p < 0.001).