Figure 7.

Inhibition of SERCA rescues enhanced presynaptic function and LTP in mature Df(16)1/+ mice. a, Cumulative rates of FM 1-43 destaining in individual boutons during 10 trains of 200 Hz tetanus (40 APs) in slices from Df(16)1/+ and WT mice in the presence of CPA (205–469 boutons). b, Mean FM 1-43 destaining rates during 10 trains of 200 Hz tetanus in presynaptic boutons of Df(16)1/+ and WT littermates in the presence or absence of CPA. c, Average calcium transients during 200 Hz tetanus (40 APs) in presynaptic boutons of Df(16)1/+ and WT littermates in the presence of CPA. d, Mean calcium transient decay times (90–10%) in response to 200 Hz tetanus in presynaptic boutons of Df(16)1/+ and WT littermates in the presence or absence of CPA. e, f, Field EPSPs as a function of time in slices from Df(16)1/+ and WT mice in the presence of CPA (e) or thapsigargin (f). Mean fEPSP₅ (g) and mean fEPSP₃₆₀ (h) in slices of Df(16)1/+ and WT mice in the absence (control) or presence of CPA or thapsigargin. *p < 0.05.