Lamins A and C |
Loss of lamins A/C causes irregular shape and reduced nuclear stiffness, as well as loss of heterochromatin; increased expression can cause nuclear invaginations. [37,39,79,92] |
Lamin B1 and B2 |
Loss of lamin B1 causes nuclear blebs; overexpression can result in nuclear lobulation; lamins B1 and B2 have little or no effect on nuclear stiffness. [39,92,93] |
Lamin B receptor (LBR) |
(Over-)expression of LBR causes nuclear lobulation and formation of excess nuclear envelope. [52,94] |
Chromatin configuration |
Stem cell-like chromatin organization causes increased nuclear plasticity and reduced stiffness; condensed chromatin increased nuclear stiffness. [53,95] |