Table 4.
Discrepancies between FISH and Metaphase Cytogenetics
| 13F | 11F | 17F | 13F 11F |
13F 17F |
13F 12F |
13F 17F 12F |
12F | 12F LOOS |
13F 11C |
13F 17C |
13C | 11C | 12C | 17C | 13F 12C |
13F 11F 12C |
11F 17C |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ABNORMAL CYTOGENETICS | |||||||||||||||||
| 51 | 3 | 4 | 7 | 3 | 1 | 1 | 1 | 2 | 1 | 2 | 1 | 2 | 1 | 6 | 1 | 1 | 1 |
| NORMAL CYTOGENETICS | |||||||||||||||||
| 48 | 2 | 2 | 1 | 2 | |||||||||||||
F = Seen by FISH, not seen by conventional cytogenetics, C = Seen by conventional cytogenetics, but not by FISH. Abnormalities by conventional cytogenetics were any that included the chromosomal band of the probe. For example, 13F indicates a deletion of D13S319 by FISH, which was not observed by conventional cytogenetics and was seen in 51 cases with abnormal cytogenetics and in 48 cases with normal cytogenetics. 13 = D13S319 (FISH), chromosome band 13q14 (conventional cytogenetics), 11 = ATM (FISH), band 11q22.3 (conventional cytogenetics), 12 = D12Z3 (FISH), trisomy 12 (conventional cytogenetics), 17 = TP53 (FISH), band 17p13.1 (conventional cytogenetics).