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. 2010 Dec 1;30(48):16262–16271. doi: 10.1523/JNEUROSCI.3656-10.2010

Figure 5.

Figure 5.

Light-evoked current in WT and Opn4−/− ipRGCs. Voltage-clamp recordings (VHold = −73 mV) of light-evoked current to a 10 s, full-field, bright, white-light stimulus at −2 logI in M1 and M2 cells of WT and Opn4−/− mice. A, Representative examples of light-evoked inward current of M1 (top) and M2 (bottom) cells in a WT mouse. B, Representative examples of light-evoked inward current of M1 (top) and M2 (bottom) cells in an Opn4−/− mouse. C, Mean ± SE maximum current measured during the 10 s light stimulus in M1 (n = 8 WT; n = 10 Opn4−/−) and M2 (n = 6 WT; n = 8 Opn4−/−) cells of WT (black bars) and Opn4−/− (white bars). Notice the reduced current in the Opn4−/− M1 but not M2 cells. D, Mean ± SE total charge measured during 10 s light stimulus in M1 (n = 8 WT; n = 10 Opn4−/−) and M2 (n = 6 WT; n = 8 Opn4−/−) cells of WT (black bars) and Opn4−/− (white bars). Notice the reduced charge in the Opn4−/− M1 but not M2 cells. Gray lines indicate 0.1 s smoothing of membrane voltage. *p < 0.05, t test.