Figure 7.
Effects of light-evoked On-pathway input on light sensitivity of M1 and M2 cells. A, B, Representative responses of two M1 cells to 5 s, full-field, white light stimulus at −5 logI in the absence (A) or presence (B) of 100 μm l-AP4. C, Normalized, averaged responses of M1 cells in the absence (black, n = 8) and presence (gray, n = 5) of 100 μm l-AP4 to increasing intensities of white light fit with logistic dose–response functions (see Materials and Methods). D, E, Representative responses of two M2 cells to 5 s, full-field, white light stimulus at −5 logI in the absence (D) or presence (E) of 100 μm l-AP4. F, Normalized and averaged responses of M2 cells in the absence (black, n = 8) and presence (gray, n = 6) of 100 μm l-AP4 to increasing intensities of white light, fit with logistic dose–response functions (see Materials and Methods). Gray lines indicate 0.1 s smoothing of membrane voltage. p < 0.05, t test. Vertical scale bars: (A–E), 20 mV.