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. Author manuscript; available in PMC: 2012 Feb 1.
Published in final edited form as: Curr Opin Genet Dev. 2010 Nov 17;21(1):107–112. doi: 10.1016/j.gde.2010.10.005

Figure 2. Selected and unselected activities of senescent cells.

Figure 2

Cellular senescence contributes to four biological processes through the cell autonomous growth arrest and paracrine activities of the SASP. We hypothesize that the growth arrest and SASP are selected traits that ensure tumor suppression and facilitate tissue repair, respectively. However, the SASP also has unselected activities that can cause or contribute to tumor promotion and aging.

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