Table 3.

Comparison of primary and secondary outcomes between treatment groups

Outcome	PPI (n=22)				Placebo (n=18)				p†
	Baseline mean (SD)	End mean (SD)	Change mean (SD)	p*	Baseline mean (SD)	End mean (SD)	Change mean (SD)	p*
CQLQ	52.9 (12.0)	43.0 (14.3)	9.8 (12.2)	0.001	58.2 (11.8)	52.3 (12.8)	5.9 (11.1)	0.04	0.3
Cough Severity Score	2.9 (0.8)	1.9 (0.9)	1.0 (1.3)	0.002	2.8 (0.7)	2.0 (1.0)	0.8 (1.2)	0.009	0.7
Cough Frequency Score	6.2 (1.8)	3.0 (1.8)	3.2 (2.4)	<0.0001	6.8 (2.0)	4.5 (2.5)	2.3 (2.7)	0.002	0.3
Reflux Finding Score	7.6 (2.2)	6.9 (2.2)	0.6 (2.0)	0.2	8.3 (2.6)	8.2 (3.6)	0.1 (2.9)	0.9	0.5

^*p values obtained via paired t-tests, comparing baseline vs. end of treatment scores within each treatment group

^†p values obtained via 2 sample t-test of differences, comparing mean change between treatment groups. Nonparametric testing also performed with Wilcoxon Rank-sum tests: p=>0.05 for all comparisons in this column. CQLQ: Cough-specific Quality of Life Questionnaire: a validated 27 item disease-targeted quality of life measure