TABLE 4.

Odds ratios for inflammatory bowel disease, Crohn’s disease and ulcerative colitis by exposure to isotretinoin in secondary analyses.^*

	IBD†	UC	CD
Secondary analyses	OR (95% CI)	OR (95% CI)	OR (95% CI)
2 year minimum‡	1.67 (0.87, 3.23)	2.90 (1.17, 7.20)	0.89 (0.32, 2.52)
Age restricted§	1.55 (0.88, 2.73)	4.90 (2.05, 11.69)	0.57 (0.22, 1.49)
≥5 diagnoses□	1.76 (0.95, 3.25)	4.19 (1.61, 10.89)	0.90 (0.35, 2.27)
≥5 diagnoses & age restricted	1.76 (0.93, 3.30)	5.14 (1.90, 13.93)	0.74 (0.27, 2.01)
Acne only¶	1.82 (1.05, 3.17)	5.63 (2.41, 13.18)	0.62 (0.23, 1.63)

^*ORs were determined via conditional logistic regression models, adjusting for age, gender, region, health plan, and length of plan enrollment.

^†IBD includes cases of CD, UC, and indeterminate IBD.

^‡Results after lengthening the potential exposure period to 24 months prior to IBD diagnosis (or first 24 months of health plan enrollment for controls).

^§Results after restricting age of cases and controls to peak age of isotretinoin use: 12–45 years

^□Results after using a more stringent definition for IBD cases, requiring ≥5 diagnosis codes on separate dates

^¶Exposure limited to persons who had a diagnosis of acne coded on the same visit or prior to a prescription for isotretinoin

IBD: inflammatory bowel disease; UC: ulcerative colitis; CD: Crohn’s disease