Figure 4.

Single-unit responses during the task. A, Raster plot and perievent time histogram for a putative pyramidal neuron recorded from a control rat performing the decision-making task. Colored bars indicate odor cue (green, free choice; red, forced right; blue, forced left) and triangles indicate reward delivery (red, right; blue, left). B, Bar plots showing the percentage of units from control (black; n = 86) and NVHL (red; n = 159) rats responding with significant increases of firing during each region of interest labeled above the bars. †Differences between the number of units, computed by χ². C, Group averages of raw firing rates (top) and z scores (bottom) for PFC single units that showed a significant increase in activity during task epochs for NVHL (dashed red line) and control (solid black line) rats. Data for each epoch are aligned to the task event indicated by labels above vertical lines. Baseline firing was not different between the two groups; however, NVHL rats showed increased firing during the task. *p < 0.05 by t test of mean cell firing during regions of interest marked by blue bars above plots. Lines indicate mean and shaded regions represent ±SEM.