Figure 7.

Pharmacological modulation of task performance in NVHL and naive rats. A, Schema illustrating the modified task used for pharmacology experiments. B, C, Responding for small rewards on free-choice trials and error rate when forced to respond for small rewards were reduced in NVHL rats (n = 4; B) but not sham rats (n = 4; C) following systemic administration of the mGluR2/3 agonist LY379268, showing that reducing glutamate transmission improves behavior. D, Systemic administration of the D₂ antagonist eticlopride (Etic) impaired behavior in naive rats (n = 5). Error rate when forced to respond for small rewards and premature response rate increased with eticlopride compared with saline (SAL) treatment in the same naive rats. E, The same treatment did not alter behavior in NVHL rats (n = 5). *p < 0.05 by paired t test. n.s., Not significant.