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Kaplan-Meier survival curves demonstrating the effect of CIMP status on survival according to 5-FU based chemotherapy treatment. In patients with CIMP-negative tumors (panel A), adjuvant chemotherapy clearly provides a survival benefit with a higher probability of disease-free survival (DFS). In patients with CIMP-positive tumors (panel B), the use of 5-FU based adjuvant chemotherapy does not improve DFS. Vertical tick marks indicate censored events.
