Table 4.
Cox regression multivariate analysis of disease-free survival in stage II and III patients
| Variable | Hazard Ratio | 95% CI | p | |
|---|---|---|---|---|
| All patients | Age (<60) | 1.2 | 0.8–1.9 | 0.3 |
| Adjuvant CT | 0.5 | 0.3–0.8 | 0.002 | |
| TNM stage | 1.8 | 1.2–2.8 | 0.005 | |
| CIMP status | 1.2 | 0.8–2.0 | 0.4 | |
| All patients | Interaction CIMP-Adjuvant CT | 0.6 | 0.5–0.8 | 0.0001 |
| Interaction CIMP-Age | 1.2 | 0.9–1.5 | 0.17 | |
| Interaction Age-Adjuvant CT | 1.1 | 0.9–1.3 | 0.4 | |
| CIMP-positive | Age | 0.8 | 0.3–2.0 | 0.7 |
| Adjuvant CT | 0.8 | 0.3–2.0 | 0.6 | |
| TNM stage | 3.4 | 1.5–7.7 | 0.004 | |
| CIMP-negative | Age | 1.5 | 0.9–2.6 | 0.13 |
| Adjuvant CT | 0.4 | 0.2–0.6 | 0.0001 | |
| TNM stage | 1.3 | 0.8–2.2 | 0.3 | |
| Adjuvant CT | Age | 1.4 | 0.7–2.7 | 0.3 |
| CIMP status | 0.6 | 0.3–1.2 | 0.1 | |
| TNM stage | 2.1 | 1.1–4.0 | 0.03 | |
| No adjuvant CT | Age | 1.2 | 0.6–2.2 | 0.6 |
| CIMP status | 2.0 | 1.1–3.8 | 0.03 | |
| TNM stage | 1.6 | 0.9–2.8 | 0.1 | |
CT. Chemotherapy; CI: confidence interval.