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. Author manuscript; available in PMC: 2012 Mar 1.
Published in final edited form as: Gene Expr Patterns. 2010 Dec 13;11(3-4):202–206. doi: 10.1016/j.gep.2010.12.002

Figure 2.

Figure 2

Expression of clock proteins in mouse teeth at E14, E15 and E17. None of the four clock proteins can be detected in teeth bud and cap stages as shown here for E14 (A) and E 15 (F) (B–E and G–J). Clock protein expression in teeth was first detected at E17 (K–N). Bmal1 protein was expressed in ameloblasts, and odontoblast (K) as well as in alveolar bone osteoblasts (K). Clock is detected in ameloblasts and odontoblasts but also in dental pulp cells (L). Per1 protein expression was the strongest among the four proteins characterized, being strongly expressed in ameloblasts, odontoblasts, dental pulp, and stratum intermedium cells (M). Per2 showed similar localization with Clock but relatively stronger expression levels (N). Ameloblasts, odontoblasts and dental pulp cells were positive for Per2. Star indicated positive expression of Bmal1 in osteoblast (K). ab, ameloblast; od, odontoblast, de, dental epithelium; dm, dental mesenchyme;. HE, Hematoxylin-Eosin; Scale bars = 50 μm.