Table II.
Baseline characteristics in DIG database
| Mild-to-Moderate LVSD (n=3,263) | Severe LVSD (n=3,537) | P value | |
|---|---|---|---|
| Age (years) | 64.0 | 63.0 | 0.001 |
| Male (%) | 73.7 | 81.3 | <0.001 |
| EF (%) | 36.2 ± 4.6 | 21.5 ± 5.2 | <0.001 |
| Duration of HFrEF (months) | 29.5 ± 37.3 | 30.8 ± 36.4 | 0.13 |
| SBP (mm Hg) | 129.4 ± 19.9 | 122.5 ± 19.4 | <0.001 |
| DBP (mm Hg) | 75. 6± 11.0 | 74.3 ± 11.4 | <0.001 |
| BMI | 27.4 ± 5.3 | 26.8 ± 5.1 | <0.001 |
| DM (%) | 29.3 | 27.6 | 0.13 |
| Edema (%) | 18.8 | 21.1 | 0.02 |
| Third heart sound (%) | 20.2 | 30.7 | <0.001 |
| Congestion on X-ray (%) | 11.5 | 17.9 | <0.001 |
| Cardio-thoracic index | 0.52 ± 0.07 | 0.54 ± 0.07 | <0.001 |
| NYHA class | 2.1 ± 0.7 | 2.3 ± 0.7 | <0.001 |
| Ischemic etiology (%) | 73.2 | 68.6 | <0.001 |
| ACEI/ARB (%) | 93.3 | 95.5 | <0.001 |
| Potassium sparing diuretics (%) | 7.7 | 7.5 | 0.82 |
| Non-potassium sparing diuretics (%) | 73.7 | 82.6 | <0.001 |
| Nitrates (%) | 41.8 | 43.4 | 0.18 |
| Hydralazine (%) | 2.1 | 2.1 | 0.93 |
ACEI/ARB: angiotensin converting enzyme inhibitors/angiotensin receptor blockers; BMI: body mass index; DBP: diastolic blood pressure; DIG: Digitalis Investigation Group; DM: diabetes mellitus; EF: ejection fraction; HFrEF: heart failure with reduced ejection fraction; LVSD: left ventricular systolic dysfunction; NYHA: New York Heart Association; SBP: systolic blood pressure. Data are represented as mean±SD for continuous variables and as percentage for categorical variables.