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. Author manuscript; available in PMC: 2012 Feb 1.
Published in final edited form as: J Mol Graph Model. 2010 Nov 11;29(5):608–613. doi: 10.1016/j.jmgm.2010.11.004

Figure 4.

Figure 4

a) The value of the propargyl linker and substitution at the C6 position is evident in a comparison with trimethoprim b) Surface rendering of the active site of human DHFR bound to TMP (white, from the crystal structure 2W3A), docked compounds 25 (purple) and 35 (tan).