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. Author manuscript; available in PMC: 2012 Mar 1.
Published in final edited form as: Anesthesiology. 2011 Mar;114(3):624–632. doi: 10.1097/ALN.0b013e31820a4edb

Figure 2. Development of mechanical allodynia following spinal nerve ligation (SNL) and baseline responding for electrical stimulation of the ventral tegmental area in control and SNL rats.

Figure 2

(A) Paw withdrawal thresholds (PWT) were assessed between 14–21 days after surgery using von Frey filaments in control and SNL rats. (B) Frequency-response curves for baseline responding were generated by averaging the third and fourth components preceding saline administration (prior to any drug treatments). The y-axis indicates the number of self-stimulations (0.5-sec) during each 50-sec trial for each frequency (x-axis). Data shown are averages across control (n=11) and SNL (n=11) rats. Average current intensities during baseline responding were 139.6 (14.23) uA for control and 138.6 (9.83) uA for SNL rats. # Significantly different from control rats P ≤ 0.05.