Table 1.
Pharmacokinetic parameters from simultaneous fitting of the BLI data and the corresponding tumor volumes as measured by ultrasound. The errors are the standard deviation calculated from 100 independent parameterization runs (see Methods).
| Mouse | Day |
kbt (x10−4 min−1) |
ktb (x10−2 min−1) |
ka (x10−2 min−1) |
kel (x10min−1) |
Volume (mm3) |
|---|---|---|---|---|---|---|
| 1 | 5 | 9.0 (1.7) | 7.9 (1.4) | 8.1 (1.4) | 1.34 (0.13) | 12.7 |
| 7 | 102 (10) | 29.9 (2.6) | 3.13 (0.27) | 60.9 | ||
| 10 | 319 (49) | 37.5 (7.1) | 3.56 (0.28) | 444 | ||
| 2 | 5 | 4.0 (1.4) | 3.15 (0.59) | 6.0 (1.9) | 1.39 (0.28) | 9.94 |
| 7 | 25 (11) | 4.5 (1.2) | 12.9 (3.7) | 59.3 | ||
| 10 | 181 (25) | 17.9 (3.8) | 3.66 (0.33) | 416 | ||
| 3 | 5 | 2.27 (0.63) | 2.70 (0.71) | 11.1 (1.7) | 1.27 (0.09) | 3.43 |
| 7 | 25.1 (2.0) | 8.76 (0.30) | 10.2 (5.3) | 43.4 | ||
| 10 | 122 (8.4) | 21.6 (1.5) | 3.8 (2.5) | 327 | ||
| 4 | 5 | 0.437 (0.046) | 2.07 (0.25) | 34.0 (5.5) | 0.61 (0.13) | 3.56 |
| 7 | 5.5 (1.1) | 7.5 (1.1) | 7.9 (1.5) | 15.8 | ||
| 10 | 15.5 (4.2) | 11.2 (1.1) | 11.3 (1.9) | 112 | ||
| 5 | 5 | 2.68 (0.75) | 3.78 (0.53) | 12.9 (2.0) | 2.43 (0.33) | 5.98 |
| 7 | 82.2 (8.5) | 41.8 (9.6) | 2.11 (0.03) | 22.7 | ||
| 6 | 5 | 0.88 (0.23) | 1.51 (0.36) | 8.4 (1.9) | 1.45 (0.19) | 3.91 |
| 7 | 3.60 (0.43) | 4.34 (0.26) | 16.3 (1.9) | 12.8 | ||