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. Author manuscript; available in PMC: 2012 Mar 25.
Published in final edited form as: Chem Biol. 2011 Mar 25;18(3):336–343. doi: 10.1016/j.chembiol.2010.12.009

Figure 1.

Figure 1

Sequences and three-dimensional structure of hepcidin. (A). Sequence alignment of selected hepcidin sequences illustrating the high sequence conservation and the N-terminal region essential for biological activity. The sequences contain eight conserved cysteines that form four disulfide bonds, indicated by the lines above the sequence list. (B). A ribbon depiction of the three-dimensional structure of hepcidin showing the β-sheet structure (broad arrows) and the four disulfide bonds (ball and sticks).