Table 1.

Bioactivity data for hepcidin analogues relative to native hepcidin.^a

Peptide	% activity relative to hepcidin ± SEMb
hepcidin	100
D1A	67 ± 5
T2A	88 ± 13
H3A	49 ± 1
F4A	33 ± 18
P5A	77 ± 3
I6A	31 ± 4
H3F	92 ± 0.3
H3W	56 ± 5
H3h	73 ± 2
H3Dabc	14 ± 0.1
H3K	9 ± 2
H3D	7 ± 6
F4Chad	88 ± 8
F4Nlee	105 ± 11
F4Y	75 ± 22
F4f	29 ± 15
F4K	15 ± 15
F4D	12 ± 10
I6F	64 ± 4
I6i	55 ± 2
I6K	18 ± 12
I6D	2 ± 5
I8K	87 ± 5
P5Of	89 ± 2

^aActivity relative to native hepcidin using the GFP-ferroportin assay.

^bn = 3 - 6

^cdiaminobutyric acid.

^dcyclohexylalanine.

^enorleucine.

^fhydroxyproline