Table 4.
Median differences in vital signs at 3 h of therapy
| Phenylephrine | Dopamine | Norepinephrine | p1 | |
|---|---|---|---|---|
| MAP (n = 69), mm Hg | 10 (4, 16) | 9 (4, 20) | 18 (10, 22) | 0.34 |
| CPP (n = 48), mm Hg | 10 (5, 20) | 13.5 (4.5, 22.5) | 26 (12, 32) | 0.32 |
| ICP (n = 48), mm Hg | 0 (−7, 6) | −3.5 (−6,-0.5) | −2 (−8, 0) | 0.23 |
| Heart rate (n = 68), bpm | −4 (−16, 1) | 2 (−7, 15) | −6 (−20, 1) | 0.09 |
Median differences with IQR in parentheses in vital signs 3 h after initiation of vasoactive medication in patients treated with a single agent compared to baseline (only patients with baseline and 3-hour measurements are included for each parameter).
1
Kruskal-Wallis equality-of-populations rank test.