Fig. 5.

Nestin-HSV-TK mice treated from P7 to P14 have impaired myelination and motor function. Western blot analysis was performed on hippocampal tissue from P15 animals for MBP, which was highly diminished in animals treated from P7 to P14 (a). At P15, animals were tested for motor function using a wire hang device, and those treated from P7 to P14 were impaired compared to controls (b; n = 5 for each group). ∗ p < 0.05. Gan = Ganciclovir.