Figure 1.

Post-genomic experiments can give insight into gene function. Owing to genome-wide HTP studies, an ever-increasing number of genes are associated from experimentally derived information, such as (a,c) mutant phenotypes, (b) enzymatic activity, (c) gene expression, and (d) protein-protein interactions (PPI). These experiments can provide different and complementary “clues” about the function of a gene or protein; however, these clues are often reliant on accurate annotation of associated genes (see Caveats ). In a worst case scenario, the gene is found to associate with misannotated genes, which can lead to erroneous predictions and misdirected experiments.