Table 1.
Genome-wide studies
| (a) Bacterial knock-out collections and initial genome-wide phenotype screens | ||
|---|---|---|
| Organism | Screen mutants for: | Refs. |
| Acinetobacter baylyi ADP1 | Carbon source utilization and colony size | [68] |
| Francisella novicida | Host colonization | [69, 70] |
| Francisella tularensis | Host colonization | [71] |
| Mesorhizobium loti | Nodulation deficiency | [72] |
| Pseudomonas aeruginosa PA14 | Abiotic surface attachment | [73] |
| Salmonella enteric serovar Typhi | Defects in growth under standard growth conditions and presence/absence of ox bile | [74] |
| Streptococcus pneumoniae | Fitness under standard growth conditions | [23] |
| Vibrio cholerae | Motility | [75] |
| (b) Genome-wide PPI studies in microbes | ||
| Organism | Strategy | Refs. |
| Escherichia coli | His-tagged bait/prey pull-down | [51] |
| Campylobacter jejuni | HTP yeast two-hybrid (Y2H) screens | [76] |
| Mezorizobium loti | HTP Y2H screens | [77] |
| Saccharomyces cerevisiae | Tandem affinity purification | [78] |
| Synechocystis sp. PCC6803 | HTP Y2H screens | [79] |
| Treponema pallidum | HTP Y2H screens | [80] |