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. Author manuscript; available in PMC: 2012 Mar 4.
Published in final edited form as: Cell. 2011 Mar 4;144(5):810–823. doi: 10.1016/j.cell.2011.02.018

Figure 7. Training-induced increase of Arc, pCREB and pcofilin are completely blocked by DAB and significantly rescued by L-lactate.

Figure 7

Mean %, n and detailed statistic are reported in Table S6.

(A-F) Examples (A) and densitometric western blot analysis of Arc (B), pCREB (C), CREB (D), pcofilin (E) and cofilin (F) performed on dorsal hippocampal extracts from trained and untrained rats injected 15 min before training with vehicle, DAB+vehicle or DAB+L-lactate and euthanized 30 min (for Arc) or 20 hr (for all other markers) after training. See also Figure S3.

Arc (B), pCREB (C) and pcofilin (E) expression were significantly increased after training. This increase was completely blocked by DAB and rescued by L-lactate. There is no change in expression of CREB (D) and cofilin (F) across samples (n=4-7/group). Data are expressed as mean percentage ± SEM of untrained, vehicle-injected control (100%) mean values. All proteins values were normalized to those of actin. * p < 0.05.