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. Author manuscript; available in PMC: 2012 Feb 1.
Published in final edited form as: Circ Cardiovasc Genet. 2010 Dec 2;4(1):16–25. doi: 10.1161/CIRCGENETICS.110.940858

Figure 4.

Figure 4

(A-D) RT-PCR analysis of transcript abundance in whole blood from KD patients during the acute and convalescent phase and association between genotype and gene expression. Relative transcript abundance levels were normalized by TAF1B for ACVRL1 (A), SMAD1 (B), SMAD3 (C) and TGFBR3 (D). Solid line: subjects with normal coronary arteries, Dashed line: subjects with coronary artery aneurysms. p value by paired t-test. (E-G) Association between acute and convalescent gene expression levels and ACVRL1 rs11169953 (risk allele= G, GG: n=7, GA: n=5, AA: n=2) (E), SMAD1 rs6537355 (risk allele=A, AA: n=9, AG: n=5, no subject had GG genotype). (F), SMAD3 rs4776338 (risk allele= G, AA: n=6, AG: n=5, GG: n=3) (G). p value by Kruskal-Wallis test (E, G) and Mann Whitney test (F).