Table 2. TDT analysis of genetic variants and KD susceptibility in US/UK/Australian trios (n=451)^*.

Chr.	Gene	rs number	Allele 1/2	Allele 2			OR	95%CI		p†
				Frequency	Transmitted	Untransmitted
1	TGFB2	rs2796817	A/C	0.13	139	98	1.42	1.10	1.84	0.0092
3	TGFBR2	rs11466480	A/C	0.03	12	27	0.44	0.23	0.88	0.024
15	SMAD3	rs4776338	A/G	0.42	272	181	1.50	1.25	1.81	0.000022
		rs7162912	C/A	0.31	229	174	1.32	1.08	1.60	0.0071
		rs12901071	A/G	0.29	230	169	1.36	1.12	1.66	0.0026
		rs1438386	A/G	0.41	190	237	0.80	0.66	0.97	0.026
		rs6494633	G/A	0.43	174	219	0.80	0.65	0.97	0.026

^*Results are shown only for SNPs with a nominal p-value <0.05

^†p values <0.0003 remained significant after Bonferroni correction

OR: odds ratio, CI: confidence interval