TABLE 1.
OAT-NUC | Remaining OAT | p | |||
---|---|---|---|---|---|
N=124 | N=2077 | ||||
DEMOGRAPHICS | N | N | |||
Age (mean, years) | 124 | 59±11 | 2077 | 59±11 | 0.95 |
Female (%) | 26 | 21.0 | 458 | 22.0 | 0.78 |
Race Black (%) | 3 | 2.4 | 66 | 3.2 | |
Hispanic (%) | 17 | 13.7 | 260 | 12.5 | |
Other (%) | 5 | 4.0 | 87 | 4.2 | 0.95 |
CLINICAL HISTORY | |||||
Hypertension (%) | 66 | 53.2 | 1005 | 48.4 | 0.30 |
Diabetes (%) | 21 | 16.9 | 433 | 20.8 | 0.30 |
On Insulin (%) | 7 | 5.6 | 117 | 5.6 | 1.00 |
Hypercholesterolemia (%) | 64 | 51.6 | 1078/2076 | 51.9 | 0.95 |
Angina (%) | 27 | 21.8 | 468 | 22.5 | 0.84 |
Prior MI* (%) | 8 | 6.4 | 239 | 11.5 | 0.08 |
Prior CHF† (%) | 3 | 2.4 | 49/2075 | 2.4 | 1.00 |
Cerebrovascular Disease (%) | 11 | 8.9 | 71 | 3.4 | 0.005 |
Prior Stroke (%) | 9 | 7.3 | 54 | 2.6 | 0.008 |
Peripheral Vascular Disease (%) | 2 | 1.6 | 81/2075 | 3.9 | 0.33 |
Family History CAD‡ (%) | 52 | 41.9 | 831 | 40.0 | 0.67 |
Current Smoker (%) | 51 | 41.1 | 808 | 38.9 | 0.62 |
History of PCI§ (%) | 3 | 2.4 | 102 | 4.9 | 0.21 |
Renal Insufficiency (%) | 2 | 1.6 | 28 | 1.4 | 0.68 |
CLINICAL MEASURES_ | |||||
BMI‖ (kg/m2) | 123 | 28 ± 5 | 2062 | 29 ± 5 | 0.10 |
Heart Rate (bpm) | 124 | 70 ± 11 | 2074 | 72 ± 12 | 0.12 |
Systolic BP# (mmHg) | 124 | 120 ± 15 | 2075 | 121 ± 18 | 0.76 |
Diastolic BP (mmHg) | 124 | 74 ± 10 | 2075 | 72 ± 11 | 0.05 |
INDEX MI | |||||
Days MI to Randomization (Median[IQR}) | 124 | 14.5 [7–23] | 2077 | 8.0 [5–16] | <0.001 |
Ejection Fraction (mean, %) | 122 | 48 ± 11 | 2063 | 48 ± 11 | 0.61 |
EF** ≥ 50% (%) | 53/122 | 43.4 | 962/2063 | 46.6 | 0.49 |
Highest Killip Class II–IV (%) | 23 | 18.6 | 394/2068 | 19.0 | 0.89 |
STE / Q waves / R wave loss (%) | 104 | 83.9 | 1801 | 86.7 | 0.37 |
ANGIOGRAPHY | |||||
Infarct Related Artery-LAD†† (%) | 39 | 31.5 | 754 | 36.3 | |
- LCX‡‡ (%) | 21 | 16.9 | 314 | 15.1 | |
- RCA§§ (%) | 64 | 51.6 | 1009 | 48.6 | 0.54 |
Multivessel Disease(%) | 25/123 | 20.3 | 354/2060 | 17.2 | 0.37 |
Collaterals - Grade 1 or 2 (%) | 108/123 | 87.8 | 1814/2050 | 88.5 | 0.82 |
Collaterals - Grade 2 (%) | 10/123 | 8.1 | 364/2050 | 17.8 | 0.006 |
MI=myocardial infarction,
CHF=congestive heart failure,
CAD=coronary artery disease,
PCI=percutaneous coronary intervention,
BMI=body mass index,
BP=blood pressure,
EF=ejection fraction,
LAD=left anterior descending artery,
LCX= left circumflex coronary artery,
RCA= right coronary artery.