TABLE 2.
OAT-NUC Patient Characteristics by Treatment Assignment
| PCI* | MED† | ||||
|---|---|---|---|---|---|
| (N = 61) | (N = 63) | p-value | |||
| % or | % or | ||||
| n | Mean±SD | n | Mean±SD | ||
| DEMOGRAPHICS | |||||
| Age (mean, years) | 61 | 58.5±11.5 | 63 | 58.6±10.6 | 0.93 |
| Female(%) | 15 | 24.6 | 11 | 17.5 | 0.33 |
| Race Black(%) | 1 | 1.6 | 2 | 3.2 | |
| Hispanic(%) | 9 | 14.8 | 8 | 12.7 | |
| Other(%) | 1 | 1.6 | 4 | 6.4 | 0.65 |
| CLINICAL HISTORY | |||||
| Hypertension(%) | 33 | 54.1 | 33 | 52.4 | 0.85 |
| Diabetes(%) | 8 | 13.1 | 13 | 20.6 | 0.26 |
| On Insulin(%) | 1 | 1.6 | 6 | 9.5 | 0.11 |
| Hypercholesterolemia(%) | 29 | 47.5 | 35 | 55.6 | 0.37 |
| Prior Angina(%) | 12 | 19.7 | 15 | 23.8 | 0.58 |
| Prior MI‡(%) | 3 | 4.9 | 5 | 7.9 | 0.72 |
| Prior PCI*(%) | 1 | 1.6 | 2 | 3.2 | 1.00 |
| Prior CHF§(%) | 2 | 3.3 | 1 | 1.6 | 0.62 |
| Cerebrovascular Disease(%) | 5 | 8.2 | 6 | 9.5 | 0.80 |
| Prior Stroke(%) | 5 | 8.2 | 4 | 6.4 | 0.74 |
| Peripheral Vascular Disease(%) | 2 | 3.3 | 0 | 0.0 | 0.24 |
| Current Smoker(%) | 24 | 39.3 | 27 | 42.9 | 0.69 |
| Family History CAD‖ (%) | 22 | 36.1 | 30 | 47.6 | 0.19 |
| CLINICAL MEASURES | |||||
| BMI# (kg/m2) | 61 | 28.4±4.6 | 62 | 27.2±4.2 | 0.16 |
| Heart Rate (bpm) | 61 | 69.9±10.9 | 63 | 70.4±10.6 | 0.77 |
| Systolic BP** (mmHg) | 61 | 119.0±15.2 | 63 | 121.7±14.5 | 0.31 |
| Diastolic BP (mmHg) | 61 | 73.4±10.3 | 63 | 75.1±9.4 | 0.33 |
| Fasting Glucose(mg/dl) | 57 | 112.0±48.7 | 62 | 109.3±26.8 | 0.72 |
| Estimated GFR†† 30–59(%) | 7 | 11.5 | 7 | 11.1 | |
| 60–89(%) | 35 | 57.4 | 34 | 54.0 | |
| ≥ 90(%) | 19 | 31.2 | 22 | 34.9 | 0.90 |
| INDEX MI | |||||
| Days from MI | 61 | 14.7±8.6 | 63 | 15.5±7.8 | 0.63 |
| Ejection Fraction (mean %) | 61 | 49.0±12.1 | 61 | 47.4±10.6 | 0.44 |
| EF‡‡ ≥ 50%(%) | 29 | 47.5 | 24/61 | 39.3 | 0.36 |
| ST elevation/Q wave/R loss(%) | 52 | 85.3 | 52 | 82.5 | 0.68 |
| Killip Class II–IV(%) | 16 | 26.2 | 7 | 11.1 | 0.03 |
| Mitral Regurgitation(%) | 5/40 | 12.5 | 8/38 | 21.0 | 0.31 |
| ANGIOGRAPHY | |||||
| IRA - LAD§§ (%) | 19 | 31.2 | 20 | 31.8 | |
| - LCX‖‖(%) | 11 | 18.0 | 10 | 15.9 | 0.95 |
| - RCA##(%) | 31 | 50.8 | 33 | 52.4 | |
| Multivessel disease(%) | 9 | 14.8 | 16/62 | 25.8 | 0.13 |
| Collaterals: Grade 1 or 2(%) | 54 | 88.5 | 54/62 | 87.1 | 0.81 |
| Collaterals: Grade 2(%) | 5 | 8.2 | 5/62 | 8.1 | 1.00 |
| MEDICATIONS AT HOSPITAL DISCHARGE | |||||
| Aspirin(%) | 59 | 96.7 | 60 | 95.2 | 1.00 |
| Thienopyridine (clopidogrel or ticlopidine)(%) | 52 | 85.2 | 26 | 41.3 | < 0.001 |
| Warfarin(%) | 3 | 4.9 | 3 | 14.3 | 0.08 |
| Beta Blocker(%) | 56 | 91.8 | 62 | 98.4 | 0.11 |
| Calcium channel Blocker(%) | 0 | 0.0 | 4 | 6.4 | 0.12 |
| Lipid lowering agent(%) | 56 | 91.8 | 62 | 98.4 | 0.11 |
| Spironolactone(%) | 8 | 13.1 | 4 | 6.4 | 0.20 |
| EF <40% - ACE-Inhibitor***/ARB†††(%) | 12/12 | 100.0 | 13/13 | 100.0 | 1.00 |
| MEDICATIONS AT 1 YEAR | (N = 41) | (N = 47) | |||
| Aspirin(%) | 39 | 95.1 | 38 | 80.8 | 0.04 |
| Clopidogrel(%) | 8 | 19.5 | 6 | 12.8 | 0.39 |
| Diuretic(%) | 10 | 24.4 | 15 | 31.9 | 0.43 |
| Beta Blocker(%) | 32 | 78.0 | 45 | 95.7 | 0.01 |
| Ca Blocker(%) | 1 | 2.4 | 4 | 8.5 | 0.37 |
| Lipid lowering agent(%) | 37 | 90.2 | 45 | 95.7 | 0.41 |
| Spironolactone(%) | 4 | 9.8 | 5 | 10.6 | 1.00 |
| EF <40% - ACE-Inhibitor***/ARB††† (%) | 7/9 | 77.8 | 7/8 | 87.5 | 1.00 |
*
PCI=percutaneous coronary intervention,
†
MED=medical therapy alone,
‡
MI=myocardial infarction,
§
CHF= congestive heart failure,
‖
CAD=coronary artery disease,
#
BMI=body mass index,
**
BP=blood pressure,
††
GFR= glomerular filtration rate,
‡‡
EF=ejection fraction,
§§
LAD=left anterior descending artery,
‖‖
LCX= left circumflex coronary artery,
##
RCA= right coronary artery,
***
ACE= Angiotensin-Converting Enzyme,
†††
ARB=Angiotension Receptor Blockers