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Formation of recurrent reciprocal chromosomal translocations in tumors. First, two DSBs occur at two nonhomologous chromosomes. Then the four broken ends, after escape from normal DSB repair, are synapsed and ligated to form reciprocal chromosomal translocations. Finally, recurrent translocations in tumors are generally thought to arise spontaneously as very low-frequency events that are strongly selected at the cellular level via their contributions to oncogenesis.
