Table 2.
Update on clinical trials for CSC molecular targets
| Target | Drug | Cancer | Phase | http://clinicaltrials.gov/ | Sponsor |
|---|---|---|---|---|---|
| Identifier | |||||
| Notch | MK0752 | Breast | I | NCT00106145 | Merck |
| Pancreatic | I, II | NCT01098344 | Cancer Research UK | ||
| RO4929097 | Renal cell | II | NCT01141569 | University Health Network, Toronto | |
| PF-03084014 | Leukemia | I | NCT00878189 | Pfizer | |
| Hedgehog | GDC-0449 | Solid tumors | I | NCT00968981 | Genentech |
| Colorectal | II | NCT00636610 | Genentech | ||
| PF04449913 | Hematologic | I | NCT00953758 | Pfizer | |
| BMS833923 | Basal cell | I | NCT00670189 | Bristol-Myers Squibb | |
| LDE225 | Medulloblastoma | I | NCT00880308 | Novartis |
Modified from (Ref. [44])