Table 1.

Allele frequencies and association statistics for F2 rs3136516 SNP in SLE women vs. the control women

	Caucasian Americans*				African Americans*
rs3136516	Controls (n=509)	All Cases (n=519)	CVE(−) Cases** (n=228)	CVE(+) Cases** (n=100)	Controls (n=143)	All Cases (n=102)
Alleles
A	0.563	0.516	0.515	0.470	0.178	0.088
G	0.437	0.484	0.485	0.530	0.822	0.912
P#	-	0.034	0.091	0.016	-	0.003
OR† (95%CI; P†)	-	1.22 (1.03–1.46; 0.023)	1.20 (0.96–1.49; 0.114)	1.42 (1.05–1.92; 0.024)	-	1.96 (1.08–3.58; 0.022)

^*Only successfully genotyped individuals were included in the table

^**Caucasian SLE cases with available cardiovascular data were stratified by the occurrence of cardiac and vascular events (CVE); myocardial infarction, coronary artery bypass graft surgery, percutaneous transluminal coronary angioplasty, angina pectoris, cardiac death, stroke, transient ischemic attack, congestive heart failure, blood clots, or vascular surgery

^#Comparison of the allele frequencies between cases and controls using a standard Z-test of two binomial proportions

^†Odds ratios and p-values under additive genetic effect model (AA=0, GA=1, GG=2); adjusted for recruitment site and age