Table 1.
Baseline characteristics of 126 subjects with AATD-associated emphysema
| Mean ± SD or N (%) | |
|---|---|
| Age, years | 53.8 ± 8.5 |
| Female | 34 (27%) |
| Caucasian race | 126 (100%) |
| Tobacco Status | |
| Never Smoker | 14 (11%) |
| Former Smoker* | 112 (89%) |
| Pack-Years (among former smokers) | 19.0 ± 12.4 |
| Body-Mass Index | 25.2 ± 4.3 |
| FEV1,% predicted | 46.5% ± 16.8% |
| FEV1/FVC | 0.38 ± 0.11 |
| Total Lung Capacity, % predicted | 149% ± 45% |
| GOLD Stage | |
| 1 | 21 (17%) |
| 2 | 56 (44%) |
| 3 | 47 (37%) |
| 4 | 2 (2%) |
| Transfer Factor (TLco), mmol/min/kpa | 4.9 ± 1.6 |
| Transfer Factor, % predicted | 48% ± 15% |
| CT Densitometry | |
| Adjusted Lung Density† | -956.2 ± 16.0 |
| Resting Oxygen Saturation (room air) | 93.5% ± 2.8% |
| Incremental Shuttle Walk Test | |
| Distance Walked, meters | 406 ± 203 |
| MMP-9 level (ng mL-1) | |
| Median (25th to 75th Interquartile Range) | 28.3 (17.8 - 55.4) |
*5 subjects (4%) had quit smoking 6-12 months prior to baseline. The remainder of former smokers had quit smoking >12 months prior to baseline. There were no current smokers by study exclusion criteria.
†Measured in Hounsfield Units at the 15th percentile.