Table 3.
Annualized change in measurements over study period |
||
---|---|---|
Mean (95% CI)* | P-value* | |
Spirometry† | ||
FEV1, ml | -36 (-67 to -5) | 0.025 |
FVC, ml | -6 (-113 to +102) | 0.92 |
FEV1/FVC ratio | -1% (-2% to -0.02%) | 0.046 |
Total Lung Capacity, ml† | -48 (-152 to +56) | 0.36 |
Transfer Factor (TLco), mmol/min/kpa† | -0.2 (-0.34 to -0.08) | 0.002 |
CT Densitometry | ||
Adjusted Lung Density‡ | -1.8 (-2.4 to -1.1) | <0.001 |
Resting Oxygenation Saturation (room air) | 0.2% (-0.3% to +0.6%) | 0.43 |
Incremental Shuttle Walk Test | ||
Distance Walked, meters | -8 (-23 to +6) | 0.26 |
*95% confidence interval (CI) and P-value were calculated using the paired t-test, which determined the 95% CI of the observed changes in each measurement over the study period and tested whether these changes were different than 0.
†Change in pulmonary function testing (PFT) measurements, which for the purposes of this study were measured over a 9 month period, are presented after extrapolation to an annualized (12 month) basis.
‡Measured in Hounsfield Units at the 15th percentile.