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. 2011 Apr 11;6(4):e18160. doi: 10.1371/journal.pone.0018160

Figure 1. Melanoma growth is reduced in Cd34−/− animals at day 14, with CD34 expression on vasculature.

Figure 1

A, Average tumor mass 14 days after subcutaneous injection of 5×105 B16F1-OVA cells. (Pooled from three experiments, Cd34+/+ n = 12; Cd34−/− n = 15). B, Average number of lung metastases 12 days after intravenous injection of 3×105 B16F1-OVA cells. (Cd34+/+ n = 5, Cd34−/− n = 6, *represents p<0.05; Error bars = SEM). C, Representative photomicrographs from s.c.-injected tumor sections stained for CD34 and CD31 or carbocyanine fluorescence, as indicated (CD31-red, CD34-blue, carbocyanine-green).