Figure 1. The sequence alignment of NDM-1 (chain-1) with 1ko3.pdb (chain-2); shown in the lower panel are the chemical structures of Imipenem and Meropenem.

The amino acids in this figure are colored according to the following four types: (1) acidic, red; (2) basic, dark blue; (3) hydrophobic, green; (4) hydrophilic, light blue. The sequence identity of the two proteins is about 43%.