Table 1. Induction of memory B cell responses following vaccination with RTS,S/AS01E and RTS,S/AS02D (ATP cohort for immunogenicity - B cell subset).
RTS,S/AS01E | RTS,S/AS02D | RTS,S/AS01E vs RTS,S/AS02D comparison | |||
N | Median (Q1–Q3) | N | Median (Q1–Q3) | p-value | |
Pre | 17 | 0 (0–20) | 23 | 0 (−49–0) | 0.12 |
Month 2 | 31 | 1692 (345–4997)*** | 28 | 183 (0–1429)*** | 0.013 |
Month 3 | 29 | 1330 (466–2857)*** | 32 | 1795 (662–3204)*** | 0.38 |
Month 14 | 25 | 27 (0–2451)* | 27 | 829 (25–1637)*** | 0.2 |
Footnote: Number of CS-specific spots per million total IgG-positive cells are presented.
*p<0.05.
***p<0.001, statistically significant differences against pre-vaccination values.