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. 2011 Apr 11;6(4):e18720. doi: 10.1371/journal.pone.0018720

Figure 2. Decrease in parasite biomass and IRBC accumulation in organs in infected CD8−/− mice.

Figure 2

A) Survival and (B) parasitemia of CD8−/− (n = 8), CD4−/− (n = 8) and WT (n = 10) mice infected with PbAluc. Neurologic signs of CM appeared on days 6–12 (shaded area), with death occurring 24–48 h after onset. Parasitemia (%) values are expressed as mean ± SD. In vivo bioluminescence imaging quantification of IRBC accumulation in the whole body (C) and head (D) of infected mice. Ex vivo quantification by bioluminescence imaging of IRBC accumulation in spleens (E) and brains (F) obtained from five perfused mice per group. Luminescence values (log) as mean ± SD. #p<0.01, log-rank test; *p<0.05, **p<0.01 and ***p<0.001, ANOVA followed by Bonferroni test.