Table 1.
Sample Demographics
| MA Cohort | OA cohort | |||||
|---|---|---|---|---|---|---|
| Decline | Improve | Stable | Decline | Improve | Stable | |
| # of subjects | 21 | 13 | 15 | 12 | 15 | 8 |
| Age | 60.3 (3.1) | 61.2 (3.0) | 61.9 (2.5) | 78.6 (5.2)a | 74.1 (3.9) | 72.0 (4.7) |
| Age Range | 53–65 | 55–65 | 59–65 | 68–87 | 66–79 | 66–79 |
| Gender (F/M) | 10/11 | 7/6 | 11/4 | 6/6 | 11/4 | 5/3 |
| APOE +/− | 44% | 17% | 27% | 42% | 14% | 25% |
| Education | 16.6 (2.4) | 16.6 (2.6) | 16.6 (1.4) | 16.2 (3.3) | 15.6 (3.1) | 16.1 (2.4) |
| MMSE | 29.3 (1.1) | 29.3 (1.2) | 29.2 (0.8) | 28.8 (1.8) | 29.0 (1.3) | 29.4 (1.0) |
| DRMRI | 46.5 (4.2)b | 57.6 (9.2) | 60.0 (6.8) | 45.2 (5.8)b | 54.7 (6.6) | 55.3 (10.3) |
| Vascular Risk | 0.9 (1.0) | 0.9 (0.9) | 0.9 (0.8) | 1.2 (1.1) | 1.1 (0.9) | 1.1 (0.9) |
Values are means (± s.d), % or frequencies.
a
The average age of the OA decliners is greater than other OA subjects, ANOVA p < 0.01.
b
Average DRmri for the decliners is less than other groups in both MA and OA subjects, (ANOVA p < 0.05)
APOE = apolipoprotein; DR = delayed recall; DRmri = DR at time of MRI, MA = middle age; MMSE = Mini-mental status exam; OA = old age