Table 2.

Characteristics of patients receiving short-term and sequential oral TKI therapy.

	Total (n = 938)	Short-term use of TKIs (n = 334)				Sequential use of TKIs (n = 216)
	N	N (%^*)	p	Adjusted OR	95% CI	N (%^*)	p	Adjusted OR	95% CI
Initial Treatment Date			0.011				<0.001
2006^a,^**	537	170 (32)		1.00	-	170 (32)		1.00	-
2007	401	164 (41)		1.27	0.89–1.81	46 (11)		0.34	0.21–0.54
Initial RCC Diagnosis Date			0.005				<0.001
2003–2005^**	380	122 (32)		1.00	-	99 (26)		1.00	-
2006	366	125 (34)		1.12	0.81–1.54	97 (27)		1.26	0.88–1.80
2007	192	87 (45)		1.51	0.95–2.37	20 (10)		1.02	0.52–1.99
Age			0.124				0.338
19–40 years^**	51	24 (47)		1.00	-	7 (14)		1.00	-
41–50 years	184	67 (36)		0.64	0.33–1.23	39 (21)		1.96	0.79–4.85
51–60 years	531	175 (33)		0.52	0.28–0.95	128 (24)		2.52	1.07–5.91
61–65 years	172	68 (40)		0.73	0.38–1.41	42 (24)		2.42	0.98–6.00
Gender			0.008				0.723
Male^**	686	227 (33)		1.00	-	160 (23)		1.00	-
Female	252	107 (42)		1.53	1.12–2.09	56 (22)		1.01	0.70–1.47
Benefit Plan^b			0.140				0.866
Basic/Comprehensive^**	94	34 (36)		1.00	-	20 (21)		1.00	-
HMO	136	59 (43)		1.34	0.75–2.37	33 (24)		1.47	0.74–2.93
Other^c	685	236 (34)		0.86	0.53–1.39	160 (23)		1.57	0.88–2.79
Geographic Region^d			0.092				0.326
Northeast^**	97	29 (30)		1.00	-	21 (22)		1.00	-
North-Central	233	77 (33)		1.22	0.72–2.09	61 (26)		1.27	0.69–2.33
South	444	178 (40)		1.71	1.05–2.80	91 (20)		0.91	0.52–1.62
West	153	46 (30)		1.07	0.60–1.89	39 (25)		1.12	0.59–2.14
Prior Kidney Surgery			0.503				0.140
Yes^**	402	148 (37)		1.00	-	102 (25)		1.00	-
No	536	186 (35)		0.92	0.70–1.22	114 (21)		0.74	0.53–1.02
Prior Immunotherapy			0.693				0.028
Yes^**	47	18 (38)		1.00	-	17 (36)		1.00	-
No	891	316 (35)		0.59	0.31–1.12	199 (22)		0.53	0.26–1.06

Abbreviations: TKI = tyrosine kinase inhibitor; OR = odds ratio; CI = confidence interval; RCC = renal cell carcinoma; HMO = health maintenance organization;

Row percentages;

^**

Reference group;

includes one case from 2005;

unknown in 23 cases;

Includes preferred provider organizations, exclusive provider organizations, point-of-service, and consumer-driven health care plans;

Unknown in 3 cases