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. Author manuscript; available in PMC: 2012 Apr 1.
Published in final edited form as: Hepatology. 2011 Apr;53(4):1246–1258. doi: 10.1002/hep.24156

Figure 5. Hedgehog activation in biliary atresia was accompanied by EMT in ductular cells.

Figure 5

(A-D) QRT-PCR analysis of EMT markers (i.e. N-Cadherin, Vimentin,, Snail, FSP1) in livers from pediatric patients with BA (N=9) and age-matched controls (CTL) (N=6). Gene expression data in disease livers are expressed relative to levels in control subjects and presented as box-and-whisker plots. Significance was evaluated by Wilcoxon rank-sum test. ** Significant Wilcoxon rank-sum test vs NL control. (E-F) Immunohistochemical analysis for FSP1 was performed in both livers (E) and extrahepatic biliary remnants (F) from BA patients. Final magnifications 630X (E-F).