Figure 8.

Summary of core regions of MBNL1 and MBNL3 required for repression and activation of splicing. (A) Diagram of the MBNL1 (upper panel) and MBNL3 (lower panels) protein domains and associated regions required for activation and repression. Green boxes indicate domains required for splicing activation of IR exon 11 and red boxes indicate domains required for splicing repression of cTNT exon 5. (B) Alignment of splicing activity domains among CELF2, CELF4 and the domains between the two zinc-finger pairs of MBNL1 and MBNL3. The common motifs that were identified include regions rich in A, Q, M (black boxes) and L and I (blue).