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. 2010 Nov 24;39(7):2519–2533. doi: 10.1093/nar/gkq1211

Figure 1.

Figure 1.

DtxR family transcription factors are candidates for the regulation of iron homeostasis in H. salinarum. (A) ClustalW comparison of the four putative DtxR homologs from the H. salinarum genome to those of the DtxR family proteins from other organisms, with representatives from several bacterial and archaeal clades. The black overbar depicts the winged helix–turn–helix DNA-binding domain. Residue locations labeled with a black box have been shown by previous structural studies to bind metal (1,17,48). Conserved residues are labeled underneath the comparison with a star, whereas conservatively substituted residues are labeled with two dots. Mtu, Mycobacterium tuberculosis (Entrez Protein accession is GI:61226440); Cgl, Corynebacterium glutamicum (GI:608593); Hsa, Halobacterium salinarum NRC-1 (idr2, GI:15789985; idr1, GI:15791320; troR, GI:10580129; sirR, GI:15789756); Afu, Archaeoglobus fulgidus (GI:2648555); Tko, Thermococcus kodakaraensis (GI: 57640042); Bsu, Bacillus subtilis (GI:251757298); Mja, Methanococcus jannaschii (GI:1592296). (B) Gene loci surrounding idr2 (above) and idr1 (below). Gray arrows represent open reading frames (ORFs) and the direction of the arrow designates the coding or non-coding strand. Genome coordinates in base pairs (bp) are shown underneath the gray arrows.