Figure 4.

Direct target genes of Idr1 and Idr2 are differentially expressed in the corresponding mutant strains. Data shown are genes differentially expressed in the Δidr1, Δidr2 and Δidr1Δidr2 double mutant backgrounds compared to wild type. These genes are also directly bound in their promoters or coding sequences by Idr1 (A) or Idr2 (B). Gene functions are indicated by the text color as described in the legend. Significance of Gene Ontology (GO) functional enrichment of genes in these categories is described in the text. Genes marked with asterisks are those with one or both of the computationally identified cis-regulatory motif sequences within 500 bp of their coding sequence. Gene name labels are listed in Supplementary Table S2 in the same order as depicted in each heatmap. Full details on gene functional annotations and motif sequences can also be found in Supplementary Table S2. Charts shown below each heat map indicate the overlap between the three genome-wide datasets. The first number listed in each circle indicates the number of sites bound in ChIP–chip experiments. The numbers in parentheses indicate the number of genes and operons associated with those sites.