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. Author manuscript; available in PMC: 2012 Mar 22.
Published in final edited form as: Biochemistry. 2011 Jan 26;50(11):1808–1817. doi: 10.1021/bi101859k

Figure 5.

Figure 5

Movement of Y323 suggests an induced-fit substrate recognition mechanism. The transition between the inward (green) and outward (yellow) conformations of Y323 involves a ~10 Å movement of the phenolic hydroxyl group and 1–3 Å movements of the polypeptide backbone. Atoms are color-coded as follows: C = green (inward conformation), yellow (outward conformation), or black (CAPS); N = blue; O = red; S = orange; Zn2+ = magenta sphere. In the outward conformation, Y323 donates a hydrogen bond to E34 from a neighboring molecule (gray carbon atoms). Metal coordination and hydrogen bond interactions are indicated by black and orange dashed lines, respectively.